The electronic Medicines Compendium (eMC) contains up to date, easily accessible information about medicines licensed for use in the UK. The eMC has more than 10,600 documents, all of which have been checked and approved by either the UK or European government agencies which license medicines. These agencies are the UK Medicines and Healthcare Products Regulatory Agency (MHRA) and the European Medicines Agency (EMA).

EpilepsySussex make every effort  to ensure that all the information is correct and up to date. EpilepsySussex is unable to provide a medical opinion, Our medical advice  is not to be a substitute for medical guidance from your own doctors. EpilepsySussex cannot be held responsible for any actions taken as a result of using this site. Any links made to other organisations does not imply approval by EpilepsySussex.

The below page and its content  is courtesy of eMC   www.medicines.org.uk/emc/

AEDs to treat Epilepsy 

Seizures 95 AEDs

Status Epilepticus 18 AEDs

Lennox-Gastaut Syndrome 12 AEDs

West Syndrome 3 AEDS

Rescue Medication 2 AEDs

Key to using the information below

 

Pregnancy

A   Aquate and well-controlled studies have failed to demonstrate a risk to the fetus in the first trimester of pregnancy (and there is no evidence of risk in later trimesters).

B  Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.

C Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.

D There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use in pregnant women despite potential risks.

X  Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use in pregnant women clearly outweigh potential benefits.

N FDA has not classified the drug.

Alcohol

IA  Interacts with Alcohol.

Prescription Only / Over the Counter

PO  Prescription Only

OTC  Over the Counter

Seizures  AEDs

Status Epilepticus AEDs

West Syndrome AEDs 

Lennox-Gastaut Syndrome AEDs

Rescue Medication

All links have been tested but over time they can become broken , please lets us know if any are not working at EpilepsySussex@gmail.com

INTERACTION               AED                                            WEBSITE

 

PO-C-N          Acetazolamide            https://www.medicines.org.uk/emc/search?q=Acetazolamide+

PO-C-IA                 Alzain                  https://www.medicines.org.uk/emc/search?q=Pregabalin 

PO-C-IA                 Axalid                  https://www.medicines.org.uk/emc/search?q=Pregabalin 

PO-C-IA                 Ativan                  https://www.medicines.org.uk/emc/product/5473/pil

PO-C-IA             Brivaracetam                      https://www.medicines.org.uk/emc/search?q=Brivaracetam

PO-C-IA               Briviact                  https://www.medicines.org.uk/emc/search?q=Briviact

PO-C-IA        Buccolam Midazolam   https://www.medicines.org.uk/emc/search?q=buccolam

 

PO-D-IA           Carbamazepine        https://www.medicines.org.uk/emc/search?q=Carbamazepine 

PO-C-IA            Clobazam                https://www.medicines.org.uk/emc/search?q=Clobaza

PO-X-IA            Convulex                  https://www.medicines.org.uk/emc/search?q=Valproic+Acid+

PO-N-IA            Clonazepam             https://www.medicines.org.uk/emc/product/6022

 

PO-X-IA            Depakote                 https://www.medicines.org.uk/emc/search?q=Valproic+Acid+

PO-C-IA            Desitrend                 https://www.medicines.org.uk/emc/search?q=%22Desitrend%22

PO-C-N              Diamox                   https://www.medicines.org.uk/emc/search?q=++Diamox

PO-C-IA            Diazepam                https://www.medicines.org.uk/emc/search?q=Diazepam

PO-B-N                  Epanutin               https://www.medicines.org.uk/emc/search?q=Phenytoin

PO-C-N        Eslicarbazepine Acetate   https://www.medicines.org.uk/emc/search?q=Eslicarbazepine

PO-X-IA                 Epilim                  https://www.medicines.org.uk/emc/search?q=Sodium

PO-X-IA          Epilim chrono             https://www.medicines.org.uk/emc/search?q=Sodium

PO-X-IA        Epilim chromosphere MR   https://www.medicines.org.uk/emc/search?q=Sodium

PO-X-IA              Episenta                 https://www.medicines.org.uk/emc/search?q=Sodium

PO-X-IA                Epival CR             https://www.medicines.org.uk/emc/search?q=Sodium

PO-C-IA               Fycompa               https://www.medicines.org.uk/emc/search?q=Fycompa

PO-C-N           Fosphenytoin             https://www.medicines.org.uk/emc/product/2260  

PO-C-IA           Gabapentin               https://www.medicines.org.uk/emc/search?q=Gabapentin 

PO-C-IA                Gabitril                 https://www.medicines.org.uk/emc/search?q=Tiagabine

PO-C-IA              Inovelon                 https://www.medicines.org.uk/emc/search?q=Rufinamide

PO-C-IA              Keppra                   www.medicines.org.uk/emc/search?q=Keppra

PO-C-IA                Levetiracetam      https://www.medicines.org.uk/emc/search?q=Levetiracetam

PO-C-IA                  Lamictal             https://www.medicines.org.uk/emc/search?q=Lamotrigine   

PO-C-IA                  Lecaent              https://www.medicines.org.uk/emc/search?q=Pregabalin

PO-C-IA                Lamotrigine          https://www.medicines.org.uk/emc/search?q=Lamotrigine   

PO-C-IA                  Lacosamide       https://www.medicines.org.uk/emc/search?q=Lacosamide

PO-C-IA              Lorazepam             https://www.medicines.org.uk/emc/search?q=Lorazepam+

PO-C-IA                     Lyrica              https://www.medicines.org.uk/emc/search?q=Lyrica

PO-C-IA                  Neurontin           https://www.medicines.org.uk/emc/search?q=Gabapentin 

PO-X-IA                  Nitrazepam        https://www.medicines.org.uk/emc/search?q=Nitrazepam

PO-C-IA             Oxcarbazepine       https://www.medicines.org.uk/emc/search?q=Oxcarbazepine

PO-C-IA                Rewisca               https://www.medicines.org.uk/emc/search?q=Pregabalin

PO-C-IA                Rufinamide           https://www.medicines.org.uk/emc/search?q=++Rufinamide

PO-D-IA               Phenytoin              https://www.medicines.org.uk/emc/search?q=Phenytoin

PO-C-IA          Phenytoin Sodium          https://www.medicines.org.uk/emc/search?q=Phenytoin

PO-C-IA              Pregabalin             https://www.medicines.org.uk/emc/search?q=Pregabalin

PO-C-IA              Perampanel           https://www.medicines.org.uk/emc/search?q=Perampanel

PO-D-IA                Phenobarbital      https://www.medicines.org.uk/emc/search?q=Phenobarbital

PO-D-IA            Phenobarbitone       https://www.medicines.org.uk/emc/search?q=Phenobarbital

PO-C-IA               Primidone             https://www.medicines.org.uk/emc/product/2940

PO-C-N               Piracetam              https://www.medicines.org.uk/emc/product/2991/pil 

 

PO-D-N                 Tegretol               https://www.medicines.org.uk/emc/search?q=Tegretol

PO-C-IA                Trileptal                https://www.medicines.org.uk/emc/search?q=Oxcarbazepine

PO-D-IA           Topiramate                https://www.medicines.org.uk/emc/search?q=Topiramate

PO-D-IA            Topamax                                    https://www.medicines.org.uk/emc/search?q=Topiramate

PO-X-IA               Tapclob                 https://www.medicines.org.uk/emc/search?q=%22Tapclob%22

PO-D-IA                Tegretol                https://www.medicines.org.uk/emc/search?q=%22Tegretol%22

PO-D-IA       Tegretol prolonged release  https://www.medicines.org.uk/emc/product/5932

PO-C-IA               Tiagabine                           https://www.medicines.org.uk/emc/search?q=Tiagabine

PO-C-IA                 Sabril                  https://www.medicines.org.uk/emc/search?q=Sabril

PO-X-IA         Sodium Valproate       https://www.medicines.org.uk/emc/search?q=Sodium

PO-C-N                 Vimpat                 https://www.medicines.org.uk/emc/search?q=Vigabatrin

OTC-B-N           Vitamin B6                              https://www.medicines.org.uk/emc/search?q=Vitamin+B6

PO-C-IA               Vigabatrin             https://www.medicines.org.uk/emc/search?q=Sabril

PO-X-IA               Valproic Acid         https://www.medicines.org.uk/emc/search?q=Valproic+Acid+

 

PO-X-IA                  Zebinix               https://www.medicines.org.uk/emc/search?q=%22Zebinix%22

PO-C-IA                  Zonegran           https://www.medicines.org.uk/emc/search?q=Zonegran

PO-C-IA              Zonisamide             https://www.medicines.org.uk/emc/search?q=Zonisamide 

PO-N-IA                                     Zarontin

 

All links have been tested but over time they can become broken , please lets us know if any are not working at EpilepsySussex@gmail.com

 Category 1 – phenytoin, carbamazepine, phenobarbital, primidone
For these drugs, doctors are advised to ensure that their patient is maintained on a specific manufacturer’s product


Category 2 – valproate, lamotrigine, perampanel, retigabine, rufinamide, clobazam, clonazepam, oxcarbazepine, eslicarbazepine, zonisamide, topiramate
For these drugs, the need for continued supply of a particular manufacturer’s product should be based on clinical judgement and consultation with patient and/or carer, taking into account factors such as seizure frequency and treatment history


Category 3 - levetiracetam, lacosamide, tiagabine, gabapentin, pregabalin, ethosuximide, vigabatrin 
For these drugs, it is usually unnecessary to ensure that patients are maintained on a specific manufacturer’s product unless there are specific reasons such as patient anxiety and risk of confusion or dosing error

 

 

 

How to ensure you are prescribed the same AEDs

Ask your doctor to prescribe you the  brand name so the pharmacist will  give you that AED

If your doctor writes the generic name of the AED on your prescription, ask if it can include  the name of the specific drug company.

Try to use  the same pharmacist each time as they may have a record of your AEDs and may ensure that you receive the same AED

How long does it take for seizure medicines to reach the bloodstream?


A dose of medication will reach a peak, or maximum, level in the blood 30 minutes to 4 or 6 hours after it is taken.
The peak time varies for different drugs.
The time between taking the medication and reaching the peak level depends on the specific medicine and what form it is in, for example a liquid, tablets, capsule or slow-release form.
In general, liquids are absorbed quickly.
Medications in slow-release forms are absorbed gradually over hours and produce the steadiest levels in the blood. These slow-release forms can be taken less often, once or twice a day.
Eating before a dose may also affect how long it takes to reach a peak level.
I have heard the term "half-life" used to talk about medications.


What does this mean?
A medicine's half-life is the time it takes for its level in the blood to be reduced by one-half.
The half-life of each seizure medicine depends on how quickly it is broken down and gotten rid of from the body.
How often a medicine should be taken depends on the drug’s half-life.


What's the difference between a medicine that has a short half-life and one with a long half-life?
If a medicine has a short half-life, the amount in your blood may quickly become too low to control your seizures. Medicines with short half-lives ideally should be taken several times a day.
Then you can take a smaller amount each time and your blood level will stay more stable.
Medicines with long half-lives have more stable levels over a number of hours. This let’s the medicine be taken less often.


When are seizure medicines most likely to work?
Seizure medicines work best when the amount in your system reaches a steady state or constant amount.
To keep this steady or constant amount, the medicine needs to be taken on a regular basis. The amount you take in needs to equal the amount your body gets rid of.
Just because a medicine has reached a steady state doesn’t mean that it will control seizures. Only by taking the medicine for a while (usually a number of months) can you tell if the drug is going to work for you

.
Is it normal for blood levels of seizure medicines to fluctuate?
Yes, even when someone has been taking the same medication for a long time the amount in your body will change over the course of the day.
Missed doses can also be a reason for why medicine levels change.
Dose-related side effects are more likely to occur at times of the highest (peak) levels and a seizure is more likely to occur at times of the lowest (trough) levels

Updated Jan 2019 

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