Change to Lamictal (lamotrigine) tablets packaging

28 Jun 2022

We’ve received some calls on our helpline from people who have noticed a change to the packaging of their Lamictal tablets.

We know changes to epilepsy medicine can cause concern, so we contacted GlaxoSmithKline, who make Lamictal, about this. They confirmed that the packaging has recently changed from transparent plastic blister packs to white plastic blister packs.

They confirmed there have been no changes to the medicine itself. The tablets inside are still the same as usual

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Tegretol Prolonged Release stock in the UK

17 May 2022

We have heard that some pharmacies are having trouble getting stock of Tegretol (carbamazepine) Prolonged Release tablets.

 

Update on 17 May 2022

Novartis have issued a statement saying they have addressed the recent stock issues by increasing manufacturing capacity, and that supply should now be back in line with demand. You can read the full statement on the Novartis website.

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Update on 11 May 2022

We’ve had several enquiries recently about supply of Tegretol. Novartis have told us they are in stock of all formulations and strengths, but are having some issues with restocking 200mg Tegretol prolonged release and 200mg Tegretol standard release tablets. This may be leading to some wholesalers running out of stock.

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Novartis hope to get this issue resolved by the end of May 2022.

If your pharmacy can’t get this medicine from their usual supplier, you can ask them to order direct from Novartis Customer Services on 08457 419 442 or email novartis.customercare@novartis.com. If your pharmacy is unwilling to do this, you can ask them to give you back your prescription so you can take it to another pharmacy.

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Update on 14 October 2021

We are continuing to get enquiries from people having trouble getting Tegretol Prolonged Release tablets. We have contacted the Department of Health and Social Care’s medicine supply team about this issue, and we are also in regular contact with Novartis who make this medicine. Novartis have assured us they are in stock and are sending as much as possible to wholesalers. Unfortunately, some wholesalers are still experiencing shortages due to an increase in demand for UK supplies of this medicine.

If your pharmacy can’t get this medicine from their usual supplier, you can ask them to order direct from Novartis Customer Services on 08457 419 442 or email novartis.customercare@novartis.com. If your pharmacy is unwilling to do this, you can ask them to give you back your prescription so you can take it to another pharmacy.

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Update on 11 August 2021

Novartis have told us they have had a sharp increase in demand for 200mg and 400mg Tegretol Prolonged Release tablets in the past few months. This has led to some wholesalers running out of stock. Novartis are sending out as much stock as possible, but if your pharmacist can’t get this medicine from their usual supplier, they can order direct from Novartis Customer Services using the contact details below.

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12 May 2022

There is a shortage of Wockhardt sodium valproate 200mg/5ml oral solution.

 

 

Update on 12 May 2022

Wockhardt have told us this medicine is now back in stock at wholesalers. Pharmacies should be able to get stock very soon.

 

Update on 11 April 2022

Wockhardt has told us they expect to send more stock to wholesalers at the end of April 2022. In the meantime, pharmacists can order it direct from Wockhardt customer services on 01978 661261

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Oxcarbazepine – some versions out of stock

25 Mar 2022

There is a temporary shortage of the following oxcarbazepine tablets:

• • • Trileptal 150mg /Sandoz oxcarbazepine 150mg

Novartis, who make both of these medicines, have told us they expect them to be back in stock from mid-April 2022.

Other strengths of Trileptal and Sandoz oxcarbazepine are in stock. Other manufacturers’ versions of oxcarbazepine are also available.

If you have any concerns about getting your usual medicine, please speak to your pharmacist or GP for advice.

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Epanutin oral suspension supply delay

9 Mar  2022

 

Update: 9 March 2022

Supply of this medicine is now back to normal.

 

 

3 March 2022

The makers of Epanutin (phenytoin) oral suspension have told us they are experiencing a supply delay of this medicine.

They are expecting a new shipment to arrive in the week beginning 7 March 2022. 

During this time your pharmacy may not have this medicine in stock. However, they will be able to order it from their supplier by confirming they have a patient with a prescription for it. The medicine should usually arrive the next working day. This is a temporary measure the makers of Epanutin have put in place to make sure stock doesn’t run out. 

Stock levels should be back to normal from around the 9 March

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21 Jan 2022

Epilim Chrono stock

We have received a further statement from Sanofi about this supply issue:

“Sanofi can confirm that there is supply of Epilim Chrono (sodium valproate and valproic acid) Controlled Release 200mg available in the UK.

Following minor delays in deliveries, some of our agents and wholesalers in some areas were left with limited supply of this medicine in recent weeks. 

Sanofi is working closely with stakeholders to ensure that there is improved national availability of this medicine with further supply to be received in our national distribution centre in the coming days. 

Should patients have any issues obtaining supply from their pharmacist, the pharmacist can contact Sanofi Customer Services (0800 854 430) for support.”

14 Jan 2022

We’ve heard that some pharmacies have been having trouble getting supplies of Epilim Chrono (sodium valproate) tablets.

We spoke to Sanofi, who told us there was a manufacturing delay which has led to some wholesalers running out of stock.

Sanofi say that any pharmacists having trouble getting supplies of Epilim Chrono should contact Sanofi customer services. They will be able to let pharmacists know which wholesalers have this medicine in stock.

 

NEW DRUG

Cenobamate (Xcopri)

Cenobamate (Xcopri) is used to treat focal seizures in adults.

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It’s one of the newer FDA treatments for seizures, having been approved in November 2019 in the USA. It’s also one of the most effective, at least in clinical trials, according to articles published in the journal Epilepsy Current,

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Looks like this will be approved to treat focal onset seizures by NICE in the UK on Dec 15th 2021

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Prolonged Release stock in the UK

18 Oct 2021

We have heard that some pharmacies are having trouble getting stock of Tegretol (carbamazepine) Prolonged Release tablets.

 

Tegretol Prolonged Release stock in the UK

12 Aug 2021

We have heard that some pharmacies are having trouble getting stock of Tegretol (carbamazepine) Prolonged Release tablets.

• read moreabout  tegretol  prolonged release stock in the uk

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Accord lamotrigine stock

8 Apr 2021

Accord have discontinued their 25mg lamotrigine tablets.

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Teva zonisamide stock issues

21Jan2021

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We have received another update on Teva zonisamide stock

 

Teva topiramate stock issues in the UK

25 Nov 2020

Update on 25 November 2020

Teva topiramate tablets are still out of stock. They are now due back in stock between January and March 2022

 

Teva zonisamide stock issues

25 Nov 2020

Update on 25 November 2020

We have received another update on Teva zonisamide stock:

25mg capsules: out of stock. Expected back between January and March 2021
50mg capsules: out of stock. Expected back between January and March 2021
100mg capsules: out of stock. Expected back in January 2021

 

Phenytoin sodium NRIM 100mg capsules stock

13 Nov 2020

Update on 13 November 2020

This medicine is still unavailable. We will update this page again as soon as we know when they will be back in stock

 

Actavis/Accord zonisamide capsules out of stock

5 Nov 2020

Update on 5 November 2020

This medicine is still long-term out of stock with no resupply date

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Accord lamotrigine stock

5 Nov 2020

Update on 5 November 2020

Accord lamotrigine tablets are back in stock in all strengths

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Frisium (clobazam) shortage in UK

22 Oct 2020

Frisium (clobazam) 10mg tablets expected to be out of stock until early November.

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Epilim 500mg Gastro-Resistant tablets – recall of some batches

15 Oct 2020

The Medicines and Healthcare products Regulatory Agency (MHRA) is recalling three batches of Epilim 500mg Gastro-Resistant tablets from pharmacies.

 

Carbagen (carbamazepine) discontinued in the UK

28 Sep 2020

Mylan have discontinued their version of carbamazepine, called Carbagen.

 

Carbagen has been out of stock since January 2019, so most people will have already switched to a different manufacturer’s version of carbamazepine. If you are still taking Carbagen we recommend speaking to your GP or epilepsy specialist as soon as possible, as it is unlikely there will be much stock left

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Accord lamotrigine stock

18 Sep 2020

Accord lamotrigine 50mg and 100mg tablets are out of stock in the UK. Accord expects them to be back in stock at the end of October 2020

 

Teva zonisamide stock issues

14 Sep 2020

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Update on 14 September 2020

We have received the following stock update from Teva:

25mg capsules: in stock
50mg capsules: out of stock. Expected back at the end of December 2020
100mg capsules: out of stock. Expected back at the end of November 20

 

Dr Reddy’s zonisamide capsules discontinued in the UK

13Aug2020

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Dr Reddy's Laboratories (UK) Ltd have stopped making their version of zonisamide capsules. This applies to all strength

 

Actavis/Accord zonisamide capsules out of stock

11Aug2020

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Zonisamide capsules made by Actavis/Accord are out of stock in all strengths. Actavis/Accord do not know when they will be back in stock, although they have told us it is likely to be at least 2 to 3 months.

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Teva Zonisamide 25mg and 100mg out of stock

5Aug2020

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Teva Zonisamide 25mg and 100mg capsules are temporarily out of stock. Teva expects them to be back in stock mid-September 2020.

Teva have informed us that the 50mg capsules are still available at this time.

 

Vimpat 50mg tablets out of stock

17 July 2020

Update 17 July: 

Vimpat 50mg tablets are back in stock. It may take a few days for stock to reach wholesalers, but they should be readily available by 22 July.

Original story 26 June: UCB, the makers of Vimpat, have told us they expect to run out of stock of Vimpat (lacosamide) 50mg tablets in the next 3 weeks. The tablets are likely to be out of stock for a period of 2-3 weeks. This is due to a manufacturing delay.

UCB tells us they will try to minimise any disruption by redistributing stock around the country. They have supplies of Vimpat 10mg/ml 200ml syrup as an alternative option. Any switch to a different formulation of Vimpat should be made under guidance from your doctor.

Other strengths of Vimpat tablets are not affected by this manufacturing delay and are expected to remain in stock.

We will update this page when Vimpat 50mg tablets are back in stock. If you have any concerns about this shortage, please speak to your pharmacist or doctor.

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Teva topiramate stock issues in the UK

6  July 2020

Update on 6 July 2020

Teva topiramate tablets are still out of stock. They are due back in stock between October and December 2020.

 

 

Update - 16 October 2019

Teva topiramate tablets are out of stock in all strengths. Teva expects to have them back in stock in early 2020.

Teva has stopped making topiramate capsules.

 

Accord topiramate stock in the UK

6 July 2020

Update on 6 July 2020

Accord topiramate tablets are back in stock in all strengths. They are now supplied in pots instead of blister packs.

 

 

Update on 15 May 2020

We’ve received a stock update for Accord topiramate tablets:

25mg tablets: in stock but some wholesalers are out of stock

50mg tablets: in stock

100mg tablets: out of stock. May be back in stock from September 2020

200mg tablets: out of stock. Accord does not know when they will be back in stock.

 

Vimpat 50mg tablets out of stock

26 June 2020

UCB, the makers of Vimpat, have told us they expect to run out of stock of Vimpat (lacosamide) 50mg tablets in the next 3 weeks. The tablets are likely to be out of stock for a period of 2-3 weeks. This is due to a manufacturing delay.

UCB tells us they will try to minimise any disruption by redistributing stock around the country. They have supplies of Vimpat 10mg/ml 200ml syrup as an alternative option. Any switch to a different formulation of Vimpat should be made under guidance from your doctor

 

Convulex (valproic acid) capsules shortage in the UK

25 June 2020

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Update on 25 June 2020

We have received confirmation that Convulex (valproic acid) capsules are back in stock.

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Update on 6 January 2020: 

Convulex (valproic acid) capsules are likely to be out of stock until April 2020. This shortage is due to a change in pack size leading to a supply delay.

If you take Convulex, please contact your doctor to discuss your treatment options. Your doctor may need to prescribe you a different manufacturer’s version of valproic acid or a different type of epilepsy medicine. The Department of Health and Social Care has written to healthcare professionals with advice about alternatives to Convulex.

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Original story 20 December 2019: The Department of Health and Social Care has told us there is a supply issue affecting all strengths of Convulex (valproic acid) capsules. 

The 500mg capsules are out of stock, and there is limited supply of the 150mg and 300mg capsules

 

Phenytoin sodium NRIM 100mg capsules stock

25 June 2020

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Update on 25 June 2020

Phenytoin sodium NRIM 100mg capsules are still out of stock. We will update this page when we know more about when they may be back in stock. 

 

13 January 2020

Phenytoin sodium NRIM 100mg capsules made by Accord are out of stock in the UK.

Accord expects them to be back in stock in early May 2020. This supply issue is due to a regulatory change at Accord’s manufacturing site.

The Department of Health and Social Care have written to healthcare professionals with advice about this shortage. They have advised doctors to switch patients to another version of phenytoin sodium 100mg capsules made by Flynn Pharma. Flynn Pharma have confirmed they have enough supplies to cover this shortage.

If phenytoin sodium capsules from Flynn Pharma are not suitable for you, other versions of phenytoin are available.

The Medicines and Healthcare products Regulatory Agency (MHRA) classifies phenytoin as a Category 1 epilepsy medicine. This means there can be differences between versions, which for some people could cause different side-effects or changes in their seizure control. When switching you from your usual version of phenytoin your doctor should carefully monitor you during and after the change. This monitoring should include doing blood tests to check your phenytoin levels

 

Epanutin 50mg Infatabs shortage in the UK

19 June 2020

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Update on 19 June 2020

Pfizer expects to have Epanutin Infatabs back in stock from the end of July 2020. They are continuing to supply Dilantin Infatabs from Canada to cover this shortage.

 

Update 5 November 2019: Pfizer has been in touch to say Epanutin Infatabs are still out of stock and they are expecting a further manufacturing delay. Pfizer has ordered extra supplies of Dilantin Infatabs from Canada to cover the shortfall until mid-2020.

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Update 3 May 2019: Pfizer now expects Epanutin Infatabs will be back in stock in November 2019.

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Original story 26 March 2019: Pfizer, the makers of Epanutin (phenytoin), have told us there will be a temporary shortage of Epanutin 50mg Infatabs. They expect it will be out of stock from 1 May for a few weeks. They do not know the exact date when it will be back in stock.

While Epanutin Infatabs are out of stock, Pfizer will be importing a Canadian version of chewable phenytoin tablets called Dilantin Infatabs. The active ingredient is the same, but there may be differences between Epanutin and Dilantin that for some people could affect seizure control and/or side-effects. If you need to change from one version of phenytoin to another this should be closely monitored by your doctor. This monitoring may involve doing blood tests to check that you have the right levels of phenytoin in your blood.

 

Epanutin oral suspension shortage in the UK

10 June 2020

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Update on 10 June 2020

Epanutin oral suspension is back in stock.

 

26 February 2020

Epanutin (phenytoin) oral suspension is due to be out of stock from 2 March until June 2020. While Epanutin oral suspension is out of stock, Pfizer will be importing a Canadian version of phenytoin oral suspension called Dilantin-30

 

 

Accord topiramate stock in the UK

15 May 2020

Update on 15 May 2020

We’ve received a stock update for Accord topiramate tablets:

25mg tablets: in stock but some wholesalers are out of stock

50mg tablets: in stock

100mg tablets: out of stock. May be back in stock from September 2020

200mg tablets: out of stock. Accord does not know when they will be back in stock.

 

 

Strike action in France could cause shortages of Sanofi valproate medicines

1 May 2020

Update on 1 May 2020

We have heard from some people who are having trouble getting 200mg Epilim gastro-resistant tablets from their pharmacist.

 

 

 

Accord lamotrigine stock

24 Apr 2020

Accord lamotrigine 25mg tablets are out of stock. Accord does not know when the tablets will be back in stock but has said it is likely to be months rather than weeks

 

 

 

Strike Action In France Could Cause Shortages Of Valproate
We have been advised by the pharmaceutical company, Sanofi, that there may be shortages of its valproate-based treatments in coming months.
Sanofi has experienced a significant disruption to the production of valproate due to ongoing strike action at its manufacturing plant in France.
This has already resulted in shortages of valproate semisodium over December 2019 and the drug company anticipates that ongoing issues may result in further shortages across the valproate range in the coming months.
Localised problems
A spokesperson for the company said that shortages were likely to be localised and that wherever possible, they would redistribute stock around the country to ensure that people are able to access their prescribed medication.
At the moment they are warning of localised shortages of 200mg Epilim Gastro-resistant tablets.
In a statement released this week, the company said: “Any patients who have concerns regarding stock information should contact their pharmacist who can contact their supplier to check stock availability in their area. If pharmacists have additional enquiries, they can contact Sanofi Customer Services on 0800 854 430 so that we can assist and help resolve the issue.”
Getting prescription in good time
It is important for people to take their prescription to their pharmacy in good time, rather than leaving it till the last minute.
“One of the most useful measures you can take to help you get your medicine as prescribed, is to ensure that you take your prescription to your pharmacy in good time - up to seven days before you actually need the medication,
“That way, if the pharmacy does not have your drugs in stock, it gives the pharmacist time to order stock from suppliers or to ring other pharmacies or suppliers, to access your medication elsewhere.”
See your doctor
If a particular valproate treatment is unavailable, people are advised to see their doctor to discuss an alternative form of treatment.

 

Epanutin oral suspension shortage in the UK
26 Feb b2020
Epanutin (phenytoin) oral suspension is due to be out of stock from 2 March until June 2020.

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Convulex (valproic acid) capsules shortage in the UK

6 Jan 2020

The Department of Health and Social Care has told us there is a supply issue affecting all strengths of Convulex (valproic acid) capsules.

 

Update on 6 January 2020: 

Convulex (valproic acid) capsules are likely to be out of stock until April 2020. This shortage is due to a change in pack size leading to a supply delay.

If you take Convulex, please contact your doctor to discuss your treatment options. Your doctor may need to prescribe you a different manufacturer’s version of valproic acid or a different type of epilepsy medicine. The Department of Health and Social Care has written to healthcare professionals with advice about alternatives to Convulex.

Original story 20 December 2019: The 500mg capsules are out of stock, and there is limited supply of the 150mg and 300mg capsules

 

Convulex (valproic acid) capsules shortage in the UK

20 Dec 2019

The Department of Health and Social Care has told us there is a supply issue affecting all strengths of Convulex (valproic acid) capsules.

 

Martindale oral suspension 5mg/5ml out of stock

5 Dec 2019

Martindale Pharma have told us that Tapclob clobazam 5 mgs oral suspension is out of stock due to a manufacturing problem.

• 250ml bottles due back in stock 13 December

• 150ml bottles due back in stock 20 December

All other preparations are in stock.

If you usually take Martindale Pharma Tapclob clobazam, your pharmacist may need to supply you with a different manufacturer’s version. If you have any concerns about this, speak to your GP, epilepsy specialist or epilepsy specialist nurse.

 

Epanutin 50mg Infatabs shortage in the UK

5 Nov 2019

Update 5 November 2019: Pfizer has been in touch to say Epanutin Infatabs are still out of stock and they are expecting a further manufacturing delay. Pfizer has ordered extra supplies of Dilantin Infatabs from Canada to cover the shortfall until mid-2020.

Update 3 May 2019: Pfizer now expects Epanutin Infatabs will be back in stock in November 2019

 

Gabitril (tiagabine) out of stock in the UK

24 Oct 2019

Update: 24 October 2019

Teva has told us they expect to have Gabitril (tiagabine) 10mg tablets back in stock this week. Supplies should arrive at pharmacies in the week beginning 28 October 2019.

Teva hopes to have the 5mg and 15mg strength tablets back in stock in the next few weeks.

If pharmacists are having trouble getting hold of Gabitril they can contact Teva customer services on 0800 590 502 for help.

Update: 16 September 2019

 

Teva topiramate stock issues in the UK

16 Oct 2019

Update - 16 October 2019

Teva topiramate tablets are out of stock in all strengths. Teva expects to have them back in stock in early 2020.

Teva has stopped making topiramate capsules.

If you usually take Teva topiramate, your pharmacist may need to supply you with a different manufacturer’s version. If you have any concerns about this, speak to your GP, epilepsy specialist or epilepsy specialist nurse.

Original story - 23 January 2019

 

Accord topiramate stock in the UK

10 Oct 2019

Update on 10 October 2019

Accord topiramate tablets are now out of stock in the 25mg, 50mg and 100mg strengths. Accord does not know when they will be back in stock.

The 200mg tablets are in stock.

Original story - 3 April 2019

Accord topiramate tablets are out of stock in the 50mg and 100mg strengths. Accord does not know when they will be back in stock.

The 25mg and 200mg tablets are in stock.

 

Gabitril (tiagabine) out of stock in the UK

16 Sep 2019

Update: 16 September 2019

The Department of Health and Social Care (DHSC) has written to GPs and pharmacies to say that supplies of tiagabine are currently available via specialist importers

 

Keppra 500mg tablets supply problem in the UK

29 Aug 2019

We have checked with UCB, the makers of Keppra, and there is a supply problem with Keppra 500mg.

They are not available at the wholesalers, but pharmacists can order them directly from UCB. No other dosages and formulations of Keppra are affected

 

Gabitril (tiagabine) out of stock in the UK

20 Aug 2019

Update: 19 August 2019
We have heard from Teva, the makers of Gabitril, that Gabitril will not be back in stock before the end of October. This further delay is caused by a problem with part of the manufacturing process. This is a Europe-wide issue.

Teva have also advised us that the same manufacturing problem may mean that Gabitril 10mg could experience a disruption in supply in early 2020.

If you are due to run out of Gabitril before the end of October we would advise contacting your epilepsy specialist as soon as possibleurgently. This is so you can discuss as soon as possible, what to do as soon as possible before you run out.

Update: 1 August 2019

The Department of Health and Social Care (DHSC) has confirmed that Gabitril is out of stock due to a manufacturing issue that is affecting the whole of Europe.

There is limited stock of the 10mg Gabitril tablets at some AAH and Alliance wholesale depots, but it is the DHSC’s understanding this stock will not be enough to last until the end of September. If your pharmacist is trying to track down stock, they can contact Teva customer services for help.

The DHSC has reached out to medicine importers to see if supplies of tiagabine can be sourced from overseas. However, as the manufacturing issue affects the rest of Europe, supplies may not be readily available.

If you are due to run out of Gabitril before the end of September we would advise contacting your epilepsy specialist as soon as possible. This is so you can discuss what to do in plenty of time before you run out.

Update: 25 July 2019

Gabitril tablets are now out of stock in all strengths. Teva expects to have this medicine back in stock at the end of September 2019.

We are not aware of any other companies in the UK that make tiagabine. We have contacted the Department of Health and Social Care to raise our concerns about this situation and will update this page as soon as we know more.

If you are due to run out of Gabitril tablets before the end of September speak to the healthcare professional who prescribes your medicine for advice.

Update: May 22 2019: 

15mg Gabitril tablets are still out of stock, and the 5mg tablets are now out of stock as well. Teva says they expect to have both strengths back in stock sometime between July and September 2019.

The 10mg tablets are in stock.

Original story: April 2 2019:

Gabitril (tiagabine) 15mg tablets are temporarily out of stock. Teva, the company that makes Gabitril, expects to have them back in stock towards the end of May 2019.

The 5mg and 10mg tablets are in stock, but they may not be available at all wholesalers. If your pharmacist is having trouble getting hold of Gabitril tablets they can contact Teva for help.

 

Epanutin oral suspension shortage in the UK

13 Aug  2019

Updated story 13 August 2019:

Epanutin oral suspension is still out of stock. It was hoped that it would be back in stock by now. Pfizer, the makers of Epanutin, are not yet able to provide a date when it is expected to be back in stock. If you have any concerns about this continuing shortage of Epanutin oral suspension, speak to your GP, epilepsy nurse or epilepsy specialist.

Original story 7 June 2019

 

Diazepam RecTubes (rectal diazepam) stock in UK

8 Aug 2019

Diazepam RecTubes (rectal diazepam) are out of stock in the UK in the 5mg and 10mg doses. The maker of Diazepam RecTubes, Wockhardt, does not know when it will have them back in stock.

The 2.5mg Diazepam RecTubes are in stock.

5mg and 10mg rectal diazepam tubes are available from other manufacturers.

 

Milpharm topiramate stock in the UK

7 Aug 2019

Update: 7 August 2019

Milpharm topiramate 25mg tablets have been out of stock. Milpharm now has them back in stock but needs to put the tablets through technical checks. The tablets should be available from pharmacists around the week beginning 26 August 2019.

All other strengths of Milpharm topiramate tablets are in stock.

Original story: 3 April 2019

Milpharm topiramate tablets are temporarily out of stock in the 50mg and 100mg strengths. Milpharm expects to have both strengths back in stock in the first week of May.

The 25mg and 200mg tablets are in stock.

Other manufacturer’s versions of topiramate are available. If you have any concerns about taking a different manufacturer’s version, speak to your GP, epilepsy nurse or epilepsy specialis

 

Mylan oxcarbazepine stock in the UK

1 Aug 2019

Mylan is out of stock of its version of oxcarbazepine 300mg and 600mg tablets.

The 300mg tablets are due back in stock in the week beginning 12 August 2019.

The 600mg tablets are due back in stock in the week beginning 13 September 2019.

The 150mg tablets are currently in stock.

Other manufacturers’ versions of oxcarbazepine are available. If you have any concerns about taking a different version of your medicine, speak to your GP, epilepsy nurse or epilepsy specialist

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Frisium and Epilim supply affected by delivery delay in the UK

1 Aug 2019

There has been a temporary disruption to the supply of some medicines made by Sanofi, including Epilim and Frisium. Sanofi has sent us the following statement:

“Following the implementation of a new IT system by our third-party logistics provider, Kuehne & Nagel, at their warehouse in Chapeltown, pharmacies in the UK will have experienced delays in the delivery of some Sanofi medicines.

Deliveries of Sanofi medicines have now been increased significantly and we expect stock levels at our wholesale suppliers to be back to normal by 2 August 2019

 

Recall of some batches of Vimpat tablets in the UK
26 July 2019

Update - 26 July 2019:

The MHRA is recalling more batches of Vimpat 100mg tablets which were taken out of the supply chain and later re-introduced. The affected tablets are in packs labelled with one of the following company names:

Kosei Pharma UK Ltd
MPT Pharma Ltd
Drugsrus Ltd / P.I.E. Pharma Ltd
Doncaster Pharmaceuticals Ltd
The following batches are affected:

Product and pack size
Italian batch number
Kosei batch number
Expiry date
Date of first distribution
VIMPAT 100 MG TABLETS 1 X 56 248884 248884/11 Dec-22 05/02/2019
VIMPAT 100 MG TABLETS 1 X 56 252026 252026/5 Jan-23 05/02/2019
VIMPAT 100 MG TABLETS 1 X 56 254265 254265/4 Apr-23 20/02/2019
VIMPAT 100 MG TABLETS 1 X 56 255279 255279/1 Apr-23 20/02/2019
The MHRA says if you have any of the affected tablets, you should continue taking them as normal but contact your GP practice to arrange a new prescription. Once you have a new prescription, you should return the affected batches to your pharmacist.

Original story - 28 June 2019:

The Medicines and Healthcare products Regulatory Agency (MHRA) has announced a recall of some batches of 100mg Vimpat (lacosamide) tablets.

The medicines are believed to be legitimate but were taken out of the regulated medicines’ supply chain during distribution and later re-introduced. This means that the correct transport and storage conditions cannot be guaranteed during this period and, while unlikely, could impact their effectiveness.

The affected tablets are in Italian packaging with B & S Healthcare labels. The following batches are affected:

Product and pack size
Italian batch number
B&S batch number
Expiry date
Date of first distribution
VIMPAT 100MG TABS 1 X 56 
254265

01P0324 30-APR-23 11-JAN-19
VIMPAT 100MG TABS 1 X 56 
255279

02P1067 30-APR-23 19-MAR-19
VIMPAT 100MG TABS 1 X 56 
258582

02P0892 30-JUN-23 25-MAR-19
VIMPAT 100MG TABS 1 X 56 
254265

02P0893 30-APR-23 15-MAR-19
The MH

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Gabitril (tiagabine) out of stock in the UK
25 July 2019

Update: 25 July 2019 Gabitril tablets are now out of stock in all strengths. Teva expects to have this medicine back in stock at the end of September 2019.

We are not aware of any other companies in the UK that make tiagabine. We have contacted the Department of Health and Social Care to raise our concerns about this situation and will update this page as soon as we know more.

If you are due to run out of Gabitril tablets before the end of September speak to the healthcare professional who prescribes your medicine for advice

 

Epilim Chronosphere modified release granules

12  July   2019

Epilim Chronosphere modified release 1,000mg granules are temporarily out of stock in the UK. This is due to an increase in demand. Sanofi expects to have them back in stock by mid-August 2019.

All other strengths of Epilim Chronosphere modified release granules are available. Other formulations of Epilim (sodium valproate) are also in stock.

Sanofi has advised that anyone with concerns about Epilim stock levels should speak to their pharmacist, who will be able to check stock levels in their area.

 

Accord levetiracetam stock in the UK

5  July 2019

Accord is out of stock of its version of levetiracetam 500mg tablets. Accord expects to have them back in stock by the end of August.

All other strengths of Accord levetiracetam tablets are in stock

 

Frisium temporary shortage in the UK

1  July  2019

Sanofi have told us that their supply of Frisium (clobazam) 10mg tablets has been significantly reduced over the past 2 weeks. This is due to a temporary manufacturing disruption, coupled with changes to packaging.

Sanofi say they are taking steps to speed up the delivery of Frisium to their suppliers, and expect to have stock back to normal levels by 5 July 2019.

 

Recall of some batches of Vimpat tablets in the UK

28  June  2019

The Medicines and Healthcare products Regulatory Agency (MHRA) has announced a recall of some batches of 100mg Vimpat (lacosamide) tablets.

The medicines are believed to be legitimate but were taken out of the regulated medicines’ supply chain during distribution and later re-introduced. This means that the correct transport and storage conditions cannot be guaranteed during this period and, while unlikely, could impact their effectiveness.

The affected tablets are in Italian packaging with B & S Healthcare labels. The following batches are affected:

 

Epanutin oral suspension shortage in the UK

7  June   2019

Pfizer, the makers of Epanutin (phenytoin), have told us there will be a temporary shortage of Epanutin 30mg/5ml oral suspension from the week beginning 10 June 2019. This is due to a manufacturing delay. Pfizer expect it will be out of stock until the end of July 2019.

The Department of Health & Social Care (DHSC) has sent an alert to healthcare professionals about this supply issue. They have asked GPs to make early contact with all their patients who are prescribed this medicine, to check if they have enough to last them until the end of July. If you don’t have enough supplies, you may wish to contact your GP now, rather than wait to hear from them.

While Epanutin oral suspension is out of stock, Pfizer will be importing a Canadian version of phenytoin oral suspension called Dilantin-30. The DHSC has advised GPs to switch patients who don’t have enough Epanutin oral suspension to Dilantin-30, until Epanutin is back in stock. Dilantin-30 contains the same active ingredient, and the DHSC says it can be considered equivalent to Epanutin. If you or your GP do not feel Dilantin-30 is appropriate for you, your GP should refer you to a specialist for advice.

You should not need any changes to your dose or frequency of your medicine when taking Dilantin-30. However, the Canadian patient information leaflet that comes with Dilantin-30 has different dosing information compared to the Epanutin leaflet. It’s important to follow your doctor’s instructions for taking Dilantin-30, even if these are different from the dosing information on the leaflet.

 

 

Gabitril (tiagabine) – 15mg tablets out of stock in the UK
22 May 2019

15mg Gabitril tablets are still out of stock, and the 5mg tablets are now out of stock as well. Teva says they expect to have both strengths back in stock sometime between July and September 2019.

The 10mg tablets are in stock.

April 2 2019: Gabitril (tiagabine) 15mg tablets are temporarily out of stock. Teva, the company that makes Gabitril, expects to have them back in stock towards the end of May 2019.

The 5mg and 10mg tablets are in stock, but they may not be available at all wholesalers. If your pharmacist is having trouble getting hold of Gabitril tablets they can contact Teva for help.

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Changes to Keppra (levetiracetam) dispensing in the UK

21 May 2019

UCB, the makers of Keppra, have announced changes to the way pharmacies dispense Keppra. The changes mean that some people who usually get Keppra from their pharmacist will be given generic levetiracetam instead.

 

Like many medicines, levetiracetam is available in a branded version (Keppra) and also in a number of generic versions made by different manufacturers. With most medicines, pharmacists are only able to give you the branded version of a medicine if your doctor writes the brand name on the prescription. This is because the branded version usually costs more to the NHS than the generic versions. However, since 2011 UCB has had schemes allowing pharmacies to dispense Keppra even if the brand name is not written on the prescription. This was at no extra cost to the NHS.

 

Due to recent changes to some of the schemes UCB operates with pharmacies, some pharmacies that have previously dispensed Keppra when given a generic prescription will no longer do so.

 

I have Keppra written on my prescription. Will this change affect me?

 

This change should not affect you. If the brand name Keppra is written on your prescription, your pharmacist must continue to give you Keppra.

 

My prescription just says levetiracetam, but my pharmacist usually gives me Keppra. Will this change affect me?

 

This will depend on whether or not your pharmacy is affected by the change. Some pharmacies will continue to dispense Keppra with a generic prescription, but UCB has not revealed which ones for commercial reasons. You may wish to speak to your pharmacist to see if they are affected by the change.

 

What can I do if I want to stay on Keppra, but my pharmacist says they need to start giving me generic levetiracetam?

 

Some pharmacies will still be able to dispense Keppra, so one option is to take your prescription to a different pharmacy. As UCB has not revealed which pharmacies are affected by the change, we’re not able to say which pharmacies to try

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Teva zonisamide stock in the UK
14 May 2019
Teva zonisamide capsules are temporarily out of stock. Teva expects the 25mg and 100mg capsules to be back in stock at the end of May 2019. The 50mg capsules are expected back at the end of July 2019. Other manufacturer’s versions of zonisamide capsules are available. If you have any concerns about taking a different manufacturers version, speak to your GP, epilepsy nurse or epilepsy specialist

 

 

Sabril (vigabatrin) stock in the UK
7 May 2019
Sabril (vigabatrin) tablets have been out of stock in the UK. Sanofi, who make Sabril, have told us the tablets will be back in stock at pharmacists this week

 

Epilim Chrono stock in the UK
7 May 2019
Sanofi has told us there is a temporary shortage of Epilim Chrono (sodium valproate) tablets in the 500mg and 300mg strengths. This is likely to affect supply for the next 2 weeks. Sanofi was unable to give an exact date of when these tablets would be back to full stock.

If your pharmacist can’t get your usual dose of Epilim Chrono before you run out, your doctor might prescribe you a different formulation of Epilim. This may mean you need to take your medicine more or less frequently. Your pharmacist should make this clear if this is the case. Alternatively, your doctor might prescribe you a different manufacturer’s version of sodium valproate.

If you have any questions about taking a different formulation or version of your medicine, speak to your GP, epilepsy specialist or epilepsy specialist nurse.

 

 

Epanutin 50mg Infatabs shortage in the UK
3 May 2019
Update May 3 2019: Pfizer now expects Epanutin Infatabs will be back in stock in November 2019.

Original story March 26 2019: Pfizer, the makers of Epanutin (phenytoin), have told us there will be a temporary shortage of Epanutin 50mg Infatabs. They expect it will be out of stock from 1 May for a few weeks. They do not know the exact date when it will be back in stock.

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Zonisamide 25mg And 100mg Out Of Stock
We have been informed by pharmaceutical company Actavis (which was recently acquired by Teva UK), that due to wholesaler issues, Zonisamide tablets in 25mg and 100mg are out of stock until early May 2019.

The 50mg version of the tablets are currently in stock.

According to the Medicines and Healthcare products Regulatory Agency (MHRA), zonisamide is a category 2 medication and this means that a doctor should decide, with yourself, whether it is important to always stay on the same version or whether it is ok to switch between different versions

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Epilim Chrono stock
9 Apr 2019
Update 9 April 2019: Epilim Chrono 500mg tablets are temporarily out of stock again, but Sanofi tells us they will be back in stock in the week beginning 15 April 2019

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Gabitril (tiagabine) 15mg tablets are temporarily out of stock.

2 Apr 2019

Teva, the company that makes Gabitril, expects to have them back in stock towards the end of May 2019

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Epanutin 50mg Infatabs shortage in the UK

26 March 2019
Pfizer, the makers of Epanutin (phenytoin), have told us there will be a temporary shortage of Epanutin 50mg Infatabs. They expect it will be out of stock from 1 May for a few weeks. They do not know the exact date when it will be back in stock.

While Epanutin Infatabs are out of stock, Pfizer will be importing a Canadian version of chewable phenytoin tablets called Dilantin Infatabs. The active ingredient is the same, but there may be differences between Epanutin and Dilantin that for some people could affect seizure control and/or side-effects. If you need to change from one version of phenytoin to another this should be closely monitored by your doctor. This monitoring may involve doing blood tests to check that you have the right levels of phenytoin in your blood.

If you take Epanutin Infatabs we would advise you to talk to your GP or epilepsy specialist as soon as possible. This is in case any changes need to be made to your treatment while the medicine is out of stock.

We will update this page as soon as we know more about this stock situation

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Epilim gastro-resistant tablets stock in the UK
19 Mar 2019
There has been a temporary shortage of Epilim (sodium valproate) gastro-resistant tablets in the UK. Sanofi has told us the 200mg tablets should be back with wholesalers this week. The 500mg tablets are expected to be with wholesalers in the week beginning 25 March 2019. The exact date may vary according to where you live and which wholesalers your pharmacy uses.

If your pharmacist can’t get your usual formulation and dose of Epilim before you run out, your doctor might prescribe you a different formulation (for example Epilim liquid or syrup). This may mean you need to take your medicine more or less frequently. Your pharmacist should make this clear if this is the case. Alternatively, your doctor might prescribe you a different manufacturer’s version of sodium valproate.

If you have any questions about taking a different formulation or version of your medicine, speak to your GP, epilepsy specialist or epilepsy specialist nurse.

Sanofi is still experiencing low stock with some of its valproate medicines but has assured us that they are working to manage the situation. Read Sanofi’s statement on Epilim stock levels

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Teva oxcarbazepine tablets discontinued in the UK

15 Mar 2019
Teva is discontinuing its version of oxcarbazepine tablets. It has already discontinued the 600mg and 300mg tablets, and will discontinue the 150mg tablets later this year when current stock runs out.

Other manufacturers’ versions of oxcarbazepine tablets are still available. If you have any concerns about taking a different version of oxcarbazepine speak to your GP, epilepsy nurse or epilepsy specialist.

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Trileptal (oxcarbazepine) oral suspension stock in the UK

12 Mar 2019

Trileptal (oxcarbazepine) oral suspension is temporarily out of stock in the UK. Novartis, the company that makes Trileptal, is unable to confirm when it will be back in stock.

Some wholesalers may still have some supplies left. If your pharmacist is unable to get Trileptal oral suspension from their usual wholesaler they can ring Novartis customer services for advice.

If your pharmacist can’t get hold of Trileptal oral suspension speak to your GP, epilepsy nurse or epilepsy specialist for advice. They may need to prescribe you a different version of your medicine

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Epilim Chrono stock
4 Mar 2019
We have heard that some people are having difficulty getting Epilim Chrono from their pharmacist. Sanofi has told us that 200mg and 300mg tablets are in stock. 500mg tablets have been out of stock but are expected to be available at the beginning of March. The exact date may vary according to where you live and which wholesalers your pharmacy uses.

If your pharmacist if having difficulty getting Epilim Chrono, they can contact Sanofi Customer Services for advice.

If your pharmacist can’t get your usual formulation and dose of Epilim before you run out, your doctor might prescribe you a different formulation (for example Epilim liquid or syrup). This may mean you need to take your medicine more or less frequently. Your pharmacist should make this clear if this is the case. Alternatively, your doctor might prescribe you a different manufacturer’s version of sodium valproate.

If you have any questions about taking a different formulation or version of your medicine, speak to your GP, epilepsy specialist or epilepsy specialist nurse.

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Sanofi statement about Epilim and Depakote stock levels
18 Feb 2019
Sanofi has issued the following update to its statement:

Patients may find that their normal tablet or granule preparation is substituted by their doctor for a liquid or syrup preparation of valproate and vice versa. This may result in a change to the frequency of dosing, but it is important that patients continue taking their medication and any changes are discussed with their doctor.

Original story 7 February 2019
In response to concerns about stock levels of Sanofi valproate-based medicines (Epilim and Depakote), Sanofi has issued the following statement:

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Sanofi valproate out of stock statement –

February 2019
Sanofi can confirm that supply of valproate (Epilim and Depakote) is available in the UK. Any patients who have concerns should contact their pharmacist who can contact the Sanofi customer service team so that we can assist and help resolve the issue.

Due to temporary disruption in the production of valproate at a Sanofi manufacturing site outside of the UK, stock levels for some treatments of valproate may be lower than usual. Sanofi is managing the situation carefully and working to ensure continued supply of valproate across all markets, including the UK. There are 17 different valproate-based treatments, ranging from tablets of different strengths and coatings through to granules and liquid preparations. We have notified the Department of Health & Social Care about the disruption of supply of valproate.

This temporary disruption in supply of some valproate-based treatments is not related to Brexit.

Change from 100 tablet packs to 30 tablet packs: At the request of the Medicines and Healthcare products Regulatory Agency (MHRA) pack sizes of valproate have been changed from 100 to 30 tablets. Pharmacies may therefore see that the 100 tablet packs are “unavailable” and assume that valproate is out of stock. The codes for 30 tablet packs should be use

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Epilim UK stock update
14 Feb 2019
Sanofi says that all doses and formulations of Epilim are in stock this week, apart from Epilim Chronosphere MR 500mg Modified Release Granules.

These are expected to be back in stock with pharmacists around the 20-22 February 2019

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 Neurontin (gabapentin) 400mg capsules  out of stock in the UK
8 Feb 2019
Neurontin (gabapentin) 400mg capsules are temporarily out of stock in the UK. This is due to a packaging problem affecting the quality of the blister packs. The company that makes Neurontin, Pfizer, expects to have it back in stock by the end of February.

Other doses of Neurontin are in stock

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Sanofi statement about Epilim and Depakote stock levels
7 Feb 2019
In response to concerns about stock levels of Sanofi valproate-based medicines (Epilim and Depakote), Sanofi has issued the following statement:

Sanofi valproate out of stock statement – February 2019
Sanofi can confirm that supply of valproate (Epilim and Depakote) is available in the UK. Any patients who have concerns should contact their pharmacist who can contact the Sanofi customer service team so that we can assist and help resolve the issue.

Due to temporary disruption in the production of valproate at a Sanofi manufacturing site outside of the UK, stock levels for some treatments of valproate may be lower than usual. Sanofi is managing the situation carefully and working to ensure continued supply of valproate across all markets, including the UK. There are 17 different valproate-based treatments, ranging from tablets of different strengths and coatings through to granules and liquid preparations. We have notified the Department of Health & Social Care about the disruption of supply of valproate.

This temporary disruption in supply of some valproate-based treatments is not related to Brexit.

Change from 100 tablet packs to 30 tablet packs: At the request of the Medicines and Healthcare products Regulatory Agency (MHRA) pack sizes of valproate have been changed from 100 to 30 tablets. Pharmacies may therefore see that the 100 tablet packs are “unavailable” and assume that valproate is out of stock. The codes for 30 tablet packs should be used. The Customer Services line is available for pharmacists to check on stock levels and ordering codes

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Carbagen out of stock in the UK
1 Feb 2019
Update on 1 February 2019

The Department of Health and Social Care (DHSC) has told us that Carbagen (carbamazepine) tablets will be out of stock until mid to late 2019. This applies to both the immediate-release and prolonged-release tablets (previously called Carbagen SR).

The DHSC has written to doctors advising them to switch their patients from Carbagen to Tegretol. Tegretol is another brand of carbamazepine, and is available in both immediate-release and prolonged-release tablets. If you have any concerns about taking a different version of your medicine, speak to your GP, epilepsy nurse or epilepsy specialis

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23 Jan 2019

Teva topiramate 50mg tablets are out of stock until mid-February 2019.

23 Jan 2019

The 10mg and 25mg tablets are available but low in stock.

If you usually take this medicine and dose, your pharmacist may need to supply you with a different manufacturer’s version of topiramate. If you have any concerns about this, speak to your GP, epilepsy specialist or epilepsy specialist nurse

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Epilim gastro-resistant tablets UK 500mg tablets are back in stock

16 January 2019:

Original story 11 January 2019: Epilim gastro-resistant tablets (sodium valproate) are temporarily out of stock in all doses.

Sanofi has told us the 200mg tablets will be back in stock by the end of January and the 500mg tablets will be back in stock in mid-January

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Epilim gastro-resistant tablets out of stock in UK

11 Jan 2019

Epilim gastro-resistant tablets (sodium valproate) are temporarily out of stock in all doses.

the 200mg tablets will be back in stock by the end of January and the 500mg tablets will be back in stock in mid-January.

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Frisium tablets out of stock in the UK
9 Jan 2019
Frisium (clobazam) tablets are out of stock in the UK. Sanofi expects to have them back in stock in mid-January 2019.

If you are due to run out of Frisium tablets before they come back in stock, your pharmacist may need to give you a different manufacturer’s version of clobazam. If you have any concerns about this, speak to your GP, epilepsy specialist or epilepsy specialist nurse